Intrinsic Determinants of Aβ (12–24) pH-Dependent Self-Assembly Revealed by Combined Computational and Experimental Studies

The propensity of amyloid-[Image: see text] (A[Image: see text]) peptide to self-assemble into highly ordered amyloid structures lies at the core of their accumulation in the brain during Alzheimer's disease. By using all-atom explicit solvent replica exchange molecular dynamics simulations, we...

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Detalles Bibliográficos
Autores principales: Xu, Weixin, Zhang, Ce, Derreumaux, Philippe, Gräslund, Astrid, Morozova-Roche, Ludmilla, Mu, Yuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177821/
https://www.ncbi.nlm.nih.gov/pubmed/21957446
http://dx.doi.org/10.1371/journal.pone.0024329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177821/
https://www.ncbi.nlm.nih.gov/pubmed/21957446
http://dx.doi.org/10.1371/journal.pone.0024329

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