Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

Cancer cells adopt glycolysis as the major source of metabolic energy production for fast cell growth. The HIF-1-induced PFKFB3 plays a key role in this adaptation by elevating the concentration of Fru-2,6-BP, the most potent glycolysis stimulator. As this metabolic conversion has been suggested to...

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Detalles Bibliográficos
Autores principales: Seo, Minsuh, Kim, Jeong-Do, Neau, David, Sehgal, Inder, Lee, Yong-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177832/
https://www.ncbi.nlm.nih.gov/pubmed/21957443
http://dx.doi.org/10.1371/journal.pone.0024179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177832/
https://www.ncbi.nlm.nih.gov/pubmed/21957443
http://dx.doi.org/10.1371/journal.pone.0024179

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