GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a known outcome of hepatosteatosis. Free fatty acids (FFA) induce the unfolded protein response (UPR) or endoplasmic reticulum (ER) stress that may induce apoptosis. Recent data indicate ER stress to be a major player in the progression of fatt...

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Detalles Bibliográficos
Autores principales: Sharma, Shvetank, Mells, Jamie E., Fu, Ping P., Saxena, Neeraj K., Anania, Frank A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177901/
https://www.ncbi.nlm.nih.gov/pubmed/21957486
http://dx.doi.org/10.1371/journal.pone.0025269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177901/
https://www.ncbi.nlm.nih.gov/pubmed/21957486
http://dx.doi.org/10.1371/journal.pone.0025269

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