Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling

Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors. Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to switch to a differentiating cystoblast (CB). Howeve...

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Detalles Bibliográficos
Autores principales: Harris, Robin E., Pargett, Michael, Sutcliffe, Catherine, Umulis, David, Ashe, Hilary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178012/
https://www.ncbi.nlm.nih.gov/pubmed/21238926
http://dx.doi.org/10.1016/j.devcel.2010.11.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178012/
https://www.ncbi.nlm.nih.gov/pubmed/21238926
http://dx.doi.org/10.1016/j.devcel.2010.11.019

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