Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice

OBJECTIVE: Obesity, insulin resistance, and type 2 diabetes form a tightly correlated cluster of metabolic disorders in which adipose is one of the first affected tissues. The role of hypoxia and hypoxia-inducible factor 1 (HIF1) in the development of high-fat diet (HFD)–induced obesity and insulin...

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Detalles Bibliográficos
Autores principales: Jiang, Changtao, Qu, Aijuan, Matsubara, Tsutomu, Chanturiya, Tatyana, Jou, William, Gavrilova, Oksana, Shah, Yatrik M., Gonzalez, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178277/
https://www.ncbi.nlm.nih.gov/pubmed/21873554
http://dx.doi.org/10.2337/db11-0174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178277/
https://www.ncbi.nlm.nih.gov/pubmed/21873554
http://dx.doi.org/10.2337/db11-0174

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