CD4(+)FoxP3(+) Regulatory T Cells from Gαi2(−/−) Mice Are Functionally Active In Vitro, but Do Not Prevent Colitis

BACKGROUND: Mice deficient in the inhibitory G protein subunit Gαi2 spontaneously develop a T helper 1 dominated colitis. We examined whether a defect in CD4(+)FoxP3(+) regulatory T cells (Treg) underpins the pathogenesis of colitis in the Gαi2(−/−) (Gαi2-deficient) colitis model. METHODOLOGY/PRINCI...

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Detalles Bibliográficos
Autores principales: Götlind, Yu-Yuan C., Raghavan, Sukanya, Bland, Paul W., Hörnquist, Elisabeth Hultgren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178583/
https://www.ncbi.nlm.nih.gov/pubmed/21966415
http://dx.doi.org/10.1371/journal.pone.0025073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178583/
https://www.ncbi.nlm.nih.gov/pubmed/21966415
http://dx.doi.org/10.1371/journal.pone.0025073

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