Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

DNA topoisomerase I (Top1) is over-expressed in tumour cells and is an important target in cancer chemotherapy. It relaxes DNA torsional strain generated during DNA processing by introducing transient single-strand breaks and allowing the broken strand to rotate around the intermediate Top1 – DNA co...

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Detalles Bibliográficos
Autores principales: Drwal, Malgorzata N., Agama, Keli, Wakelin, Laurence P. G., Pommier, Yves, Griffith, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178613/
https://www.ncbi.nlm.nih.gov/pubmed/21966440
http://dx.doi.org/10.1371/journal.pone.0025150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178613/
https://www.ncbi.nlm.nih.gov/pubmed/21966440
http://dx.doi.org/10.1371/journal.pone.0025150

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