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Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

DNA topoisomerase I (Top1) is over-expressed in tumour cells and is an important target in cancer chemotherapy. It relaxes DNA torsional strain generated during DNA processing by introducing transient single-strand breaks and allowing the broken strand to rotate around the intermediate Top1 – DNA co...

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Detalles Bibliográficos
Autores principales:	Drwal, Malgorzata N., Agama, Keli, Wakelin, Laurence P. G., Pommier, Yves, Griffith, Renate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178613/ https://www.ncbi.nlm.nih.gov/pubmed/21966440 http://dx.doi.org/10.1371/journal.pone.0025150

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