The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus, and PTH

Patients with neonatal severe hyperparathyroidism (NSHPT) are homozygous for the calcium-sensing receptor (CaR) mutation and have very high circulating PTH, abundant parathyroid hyperplasia, and severe life-threatening hypercalcemia. Mice with homozygous deletion of CaR mimic the syndrome of NSHPT....

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Detalles Bibliográficos
Autores principales: Liu, Jingning, Lv, Fangqiao, Sun, Wen, Tao, Chunxiang, Ding, Guoxian, Karaplis, Andrew, Brown, Edward, Goltzman, David, Miao, Dengshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178615/
https://www.ncbi.nlm.nih.gov/pubmed/21966280
http://dx.doi.org/10.1371/journal.pgen.1002294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178615/
https://www.ncbi.nlm.nih.gov/pubmed/21966280
http://dx.doi.org/10.1371/journal.pgen.1002294

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