Network Models of TEM β-Lactamase Mutations Coevolving under Antibiotic Selection Show Modular Structure and Anticipate Evolutionary Trajectories

Understanding how novel functions evolve (genetic adaptation) is a critical goal of evolutionary biology. Among asexual organisms, genetic adaptation involves multiple mutations that frequently interact in a non-linear fashion (epistasis). Non-linear interactions pose a formidable challenge for the...

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Detalles Bibliográficos
Autores principales: Guthrie, Violeta Beleva, Allen, Jennifer, Camps, Manel, Karchin, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178621/
https://www.ncbi.nlm.nih.gov/pubmed/21966264
http://dx.doi.org/10.1371/journal.pcbi.1002184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178621/
https://www.ncbi.nlm.nih.gov/pubmed/21966264
http://dx.doi.org/10.1371/journal.pcbi.1002184

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