The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization

The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc(−/−) mice displayed defective antigen presentation by dendritic cell...

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Detalles Bibliográficos
Autores principales: Ippagunta, Sirish K., Malireddi, R. K. Subbarao, Shaw, Patrick J., Neale, Geoffrey A., Vande Walle, Lieselotte, Green, Douglas R., Fukui, Yoshinori, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178750/
https://www.ncbi.nlm.nih.gov/pubmed/21892172
http://dx.doi.org/10.1038/ni.2095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178750/
https://www.ncbi.nlm.nih.gov/pubmed/21892172
http://dx.doi.org/10.1038/ni.2095

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