Catalytic Specificity of Human Protein Tyrosine Kinases Revealed by Peptide Substrate Profiling

Out of the 90 human protein tyrosine kinases, 81 were assayed with short peptides derived from well-characterized [CDK1(Tyr15), IRS1(Tyr983), and JAK1(Tyr1023)] or generic [polyGlu:Tyr(4:1) and poly-Glu:Ala:Tyr(1:1:1)] substrates. As expected, the CDK1 peptide is a substrate for all Src family kinas...

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Detalles Bibliográficos
Autores principales: Blouin, Julie, Roby, Philippe, Arcand, Mathieu, Beaudet, Lucille, Lipari, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178905/
https://www.ncbi.nlm.nih.gov/pubmed/21966344
http://dx.doi.org/10.2174/1875397301105010115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178905/
https://www.ncbi.nlm.nih.gov/pubmed/21966344
http://dx.doi.org/10.2174/1875397301105010115

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