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Catalytic Specificity of Human Protein Tyrosine Kinases Revealed by Peptide Substrate Profiling

Out of the 90 human protein tyrosine kinases, 81 were assayed with short peptides derived from well-characterized [CDK1(Tyr15), IRS1(Tyr983), and JAK1(Tyr1023)] or generic [polyGlu:Tyr(4:1) and poly-Glu:Ala:Tyr(1:1:1)] substrates. As expected, the CDK1 peptide is a substrate for all Src family kinas...

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Detalles Bibliográficos
Autores principales:	Blouin, Julie, Roby, Philippe, Arcand, Mathieu, Beaudet, Lucille, Lipari, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Open 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178905/ https://www.ncbi.nlm.nih.gov/pubmed/21966344 http://dx.doi.org/10.2174/1875397301105010115

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