Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors

In order to investigate the SAR of Ezetimibe analogs for cholesterol absorption inhibitions, amide group and electron-deficient pyridine ring were introduced to the C-(3) carbon chain of Ezetimibe. Eight new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, an...

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Detalles Bibliográficos
Autores principales: Wang, Yubin, Haiqian, Huang, Wenlong, Zhang, Huibin, Zhou, Jinpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179128/
https://www.ncbi.nlm.nih.gov/pubmed/21966284
http://dx.doi.org/10.2174/157018011795906776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179128/
https://www.ncbi.nlm.nih.gov/pubmed/21966284
http://dx.doi.org/10.2174/157018011795906776

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