Cargando…

Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors

In order to investigate the SAR of Ezetimibe analogs for cholesterol absorption inhibitions, amide group and electron-deficient pyridine ring were introduced to the C-(3) carbon chain of Ezetimibe. Eight new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yubin, Haiqian, Huang, Wenlong, Zhang, Huibin, Zhou, Jinpei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers Ltd 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179128/ https://www.ncbi.nlm.nih.gov/pubmed/21966284 http://dx.doi.org/10.2174/157018011795906776

Ejemplares similares

Effect of Ezetimibe Monotherapy on Low-Density Lipoprotein Cholesterol and on Markers of Cholesterol Synthesis and Absorption in Japanese Patients With Hypercholesterolemia
por: Ohta, Akio, et al.
Publicado: (2017)

Perfluoroalkyl Substance Serum Concentrations and Cholesterol Absorption-Inhibiting Medication Ezetimibe
por: Ma, Ge, et al.
Publicado: (2022)

Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin‐deficient and mdx mice
por: White, Zoe, et al.
Publicado: (2021)

Successful treatment of massive proteinuria and severe chyluria by inhibition of cholesterol absorption with ezetimibe in a patient with filariasis
por: Tanaka, Shigeru, et al.
Publicado: (2012)

Combination therapy in cholesterol reduction: focus on ezetimibe and statins
por: Grigore, Liliana, et al.
Publicado: (2008)

Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors
por: Dražić, Tonko, et al.
Publicado: (2015)

Synthesis and Modeling of Ezetimibe Analogues
por: Salgado, Mateo M., et al.
Publicado: (2021)

Influence of Previous Statin Therapy on Cholesterol-Lowering Effect of Ezetimibe
por: Choi, Young Hwan, et al.
Publicado: (2014)

A comparison of the effects of monotherapy with rosuvastatin, atorvastatin or ezetimibe versus combination treatment with rosuvastatin-ezetimibe and atorvastatin-ezetimibe on the integrity of vascular endothelial cells damaged by oxidized cholesterol
por: Niedzielski, Mateusz, et al.
Publicado: (2021)

Ezetimibe and Simvastatin Reduce Cholesterol Levels in Zebrafish Larvae Fed a High-Cholesterol Diet
por: Baek, Ji Sun, et al.
Publicado: (2012)

Exquisite Balance Between Cholesterol Synthesis and Cholesterol Absorption in Human
por: Tada, Hayato, et al.
Publicado: (2023)

Treatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease
por: Tadiboyina, Venu T, et al.
Publicado: (2005)

Complementary Therapy to Target LDL Cholesterol: The Role of the Ezetimibe/Simvastatin Combination
por: Neal, Ryan C, et al.
Publicado: (2006)

Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine
por: Nakano, Takanari, et al.
Publicado: (2016)

Associations between SNPs in Intestinal Cholesterol Absorption and Endogenous Cholesterol Synthesis Genes with Cholesterol Metabolism
por: Schroor, Maite M., et al.
Publicado: (2021)

The Relationship Between Cholesterol Absorption and Intestinal Cholesterol Synthesis in the Diabetic Rat Model
por: Gleeson, Aine, et al.
Publicado: (2000)

Spirogyra neglecta inhibits the absorption and synthesis of cholesterol in vitro
por: Duangjai, Acharaporn, et al.
Publicado: (2016)

What is the Role of Cholesterol Absorption and Synthesis Biomarkers in Humans?
por: Tada, Hayato, et al.
Publicado: (2023)

The pivotal role of cholesterol absorption inhibitors in the management of dyslipidemia
por: Al-Shaer, Moutasim H, et al.
Publicado: (2004)

Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies
por: Aliabadi, Alireza, et al.
Publicado: (2015)

Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors
por: Subramanian, Venkataraman, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators
por: Li, Ruo-Xin, et al.
Publicado: (2020)

Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial
por: Leyes, Pere, et al.
Publicado: (2014)

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
por: Huang, Ching-Shin, et al.
Publicado: (2020)

Novel Carbonyl Analogs of Tamoxifen: Design, Synthesis, and Biological Evaluation
por: Kasiotis, Konstantinos M., et al.
Publicado: (2017)

Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation
por: Dorst, Andrea, et al.
Publicado: (2020)

Ezetimibe: Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease
por: de Bari, Ornella, et al.
Publicado: (2012)

Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis
por: Johnson, Tory A., et al.
Publicado: (2016)

Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins
por: Bays, Harold E., et al.
Publicado: (2021)

Pharmacological Strategies beyond Statins: Ezetimibe and PCSK9 Inhibitors
por: Choi, Jah Yeon, et al.
Publicado: (2019)

Fungal biotransformation of ezetimibe
por: Pervaiz, Irfan, et al.
Publicado: (2014)

Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non‐dialysis CKD: An observational study
por: Emrich, Insa E., et al.
Publicado: (2021)

Serum Low Density Lipoprotein Cholesterol Concentration Is Not Dependent on Cholesterol Synthesis and Absorption in Healthy Humans
por: Stellaard, Frans, et al.
Publicado: (2022)

Synthesis and biological evaluation of novel quinoline analogs of ketoprofen as multidrug resistance protein 2 (MRP2) inhibitors
por: Mosaffa, Fatemeh, et al.
Publicado: (2021)

Ezetimibe reduces cholesterol content and NF-kappaB activation in liver but not in intestinal tissue in guinea pigs
por: Fraunberger, Peter, et al.
Publicado: (2017)

Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients
por: Ahmed, Osman, et al.
Publicado: (2018)

Combined Effect of Diosgenin Along with Ezetimibe or Atorvastatin on the Fate of Labelled Bile Acid and Cholesterol in Hypercholesterolemic Rats
por: Marín-Medina, Alejandro, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents
por: J. Solum, Eirik, et al.
Publicado: (2020)

Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies
por: Kasmas, S.H., et al.
Publicado: (2012)

Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors
por: Dražić, Tonko, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8rdr0lffgn8i8dnudu9hqg12li