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Continuous Elevation of PTH Increases the Number of Osteoblasts via Both Osteoclast-Dependent and -Independent Mechanisms
Sustained parathyroid hormone (PTH) elevation stimulates bone remodeling (ie, both resorption and formation). The former results from increased RANKL synthesis, but the cause of the latter has not been established. Current hypotheses include release of osteoblastogenic factors from osteoclasts or fr...
Autores principales: | Jilka, Robert L, O'Brien, Charles A, Bartell, Shoshana M, Weinstein, Robert S, Manolagas, Stavros C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179285/ https://www.ncbi.nlm.nih.gov/pubmed/20533302 http://dx.doi.org/10.1002/jbmr.145 |
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