Calpain-6, a Target Molecule of Glucocorticoids, Regulates Osteoclastic Bone Resorption via Cytoskeletal Organization and Microtubule Acetylation

Glucocorticoids (GCs) inhibit the resorptive capacity of the osteoclast by disrupting its cytoskeleton. We find that calpain-6 (Capn6), a unique, nonproteolytic member of its family, is suppressed 12-fold by dexamethasone (DEX) in the bone-degrading cell. While Capn6 abundance parallels commitment o...

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Detalles Bibliográficos
Autores principales: Hong, Jung Min, Teitelbaum, Steven L, Kim, Tae-Ho, Ross, F Patrick, Kim, Shin-Yoon, Kim, Hyun-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179291/
https://www.ncbi.nlm.nih.gov/pubmed/20814968
http://dx.doi.org/10.1002/jbmr.241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179291/
https://www.ncbi.nlm.nih.gov/pubmed/20814968
http://dx.doi.org/10.1002/jbmr.241

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