A Naturally Occurring Isoform Inhibits Parathyroid Hormone Receptor Trafficking and Signaling

Parathyroid hormone (PTH) regulates calcium homeostasis and bone remodeling through its cognitive receptor (PTHR). We describe here a PTHR isoform harboring an in-frame 42-bp deletion of exon 14 (Δe14-PTHR) that encodes transmembrane domain 7. Δe14-PTHR was detected in human kidney and buccal epithe...

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Detalles Bibliográficos
Autores principales: Alonso, Verónica, Ardura, Juan A, Wang, Bin, Sneddon, W Bruce, Friedman, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179322/
https://www.ncbi.nlm.nih.gov/pubmed/20578167
http://dx.doi.org/10.1002/jbmr.167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179322/
https://www.ncbi.nlm.nih.gov/pubmed/20578167
http://dx.doi.org/10.1002/jbmr.167

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