Activation of TRPA1 by membrane permeable local anesthetics

BACKGROUND: Low concentrations of local anesthetics (LAs) suppress cellular excitability by inhibiting voltage-gated Na(+ )channels. In contrast, LAs at high concentrations can be excitatory and neurotoxic. We recently demonstrated that LA-evoked activation of sensory neurons is mediated by the caps...

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Detalles Bibliográficos
Autores principales: Leffler, Andreas, Lattrell, Anja, Kronewald, Sergej, Niedermirtl, Florian, Nau, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179737/
https://www.ncbi.nlm.nih.gov/pubmed/21861907
http://dx.doi.org/10.1186/1744-8069-7-62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179737/
https://www.ncbi.nlm.nih.gov/pubmed/21861907
http://dx.doi.org/10.1186/1744-8069-7-62

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