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A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53
Human tumors are heterogeneous and evolve through a dynamic process of genetic mutation and selection. During this process, the effects of a specific mutation on the incipient cancer cell may dictate the nature of subsequent mutations that can be tolerated or selected for, affecting the rate at whic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179816/ https://www.ncbi.nlm.nih.gov/pubmed/21685943 http://dx.doi.org/10.1038/onc.2011.236 |