Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1

Elevated levels of active glucocorticoids have been implicated in the development of several phenotypes of metabolic syndrome, such as type 2 diabetes and obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the intracellular conversion of inactive cortisone to cortisol. Selective 1...

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Detalles Bibliográficos
Autores principales: Su, Xiangdong, Pradaux-Caggiano, Fabienne, Vicker, Nigel, Thomas, Mark P, Halem, Heather, Culler, Michael D, Potter, Barry V L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179844/
https://www.ncbi.nlm.nih.gov/pubmed/21714097
http://dx.doi.org/10.1002/cmdc.201100182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179844/
https://www.ncbi.nlm.nih.gov/pubmed/21714097
http://dx.doi.org/10.1002/cmdc.201100182

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