Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage

BACKGROUND: Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice deficient for Arx do not develop any alpha-cells whereas beta- and delta-cells are found in considerably higher numbers. In Nkx2.2 mutant animals, a...

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Detalles Bibliográficos
Autores principales: Kordowich, Simon, Collombat, Patrick, Mansouri, Ahmed, Serup, Palle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179930/
https://www.ncbi.nlm.nih.gov/pubmed/21880149
http://dx.doi.org/10.1186/1471-213X-11-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179930/
https://www.ncbi.nlm.nih.gov/pubmed/21880149
http://dx.doi.org/10.1186/1471-213X-11-52

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