The PD-1/PD-L1 (B7-H1) Pathway in Chronic Infection-Induced Cytotoxic T Lymphocyte Exhaustion

Cytotoxic CD8 T lymphocytes (CTLs) play a pivotal role in the control of infection. Activated CTLs, however, often lose effector function during chronic infection. PD-1 receptor and its ligand PD-L1 of the B7/CD28 family function as a T cell coinhibitory pathway and are emerging as major regulators...

Descripción completa

Detalles Bibliográficos
Autores principales: Hofmeyer, Kimberly A., Jeon, Hyungjun, Zang, Xingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180079/
https://www.ncbi.nlm.nih.gov/pubmed/21960736
http://dx.doi.org/10.1155/2011/451694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180079/
https://www.ncbi.nlm.nih.gov/pubmed/21960736
http://dx.doi.org/10.1155/2011/451694

Ejemplares similares