Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

BACKGROUND: Recent genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNP)s that are essentially unequivocally associated with peripheral cholesterol. Since the alleles of the APOE gene, which modulate peripheral cholesterol metabolism, and midlife plasma cholest...

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Detalles Bibliográficos
Autores principales: Simmons, Christopher R, Zou, Fanggeng, Younkin, Steven G, Estus, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180274/
https://www.ncbi.nlm.nih.gov/pubmed/21867541
http://dx.doi.org/10.1186/1750-1326-6-62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180274/
https://www.ncbi.nlm.nih.gov/pubmed/21867541
http://dx.doi.org/10.1186/1750-1326-6-62

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