Reversion of pH-Induced Physiological Drug Resistance: A Novel Function of Copolymeric Nanoparticles

AIMS: The extracellular pH of cancer cells is lower than the intracellular pH. Weakly basic anticancer drugs will be protonated extracellularly and display a decreased intracellular concentration. In this study, we show that copolymeric nanoparticles (NPs) are able to overcome this “pH-induced physi...

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Detalles Bibliográficos
Autores principales: Li, Rutian, Xie, Li, Zhu, Zhenshu, Liu, Qin, Hu, Yong, Jiang, Xiqun, Yu, Lixia, Qian, Xiaoping, Guo, Wanhua, Ding, Yitao, Liu, Baorui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180282/
https://www.ncbi.nlm.nih.gov/pubmed/21966359
http://dx.doi.org/10.1371/journal.pone.0024172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180282/
https://www.ncbi.nlm.nih.gov/pubmed/21966359
http://dx.doi.org/10.1371/journal.pone.0024172

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