Fibrillization of Human Tau Is Accelerated by Exposure to Lead via Interaction with His-330 and His-362

BACKGROUND: Neurofibrillary tangles, mainly consisted of bundles of filaments formed by the microtubule-associated protein Tau, are a hallmark of Alzheimer disease. Lead is a potent neurotoxin for human being especially for the developing children, and Pb(2+) at high concentrations is found in the b...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Hai-Li, Meng, Sheng-Rong, Fan, Jun-Bao, Chen, Jie, Liang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180286/
https://www.ncbi.nlm.nih.gov/pubmed/21966400
http://dx.doi.org/10.1371/journal.pone.0025020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180286/
https://www.ncbi.nlm.nih.gov/pubmed/21966400
http://dx.doi.org/10.1371/journal.pone.0025020

Ejemplares similares