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Fibrillization of Human Tau Is Accelerated by Exposure to Lead via Interaction with His-330 and His-362
BACKGROUND: Neurofibrillary tangles, mainly consisted of bundles of filaments formed by the microtubule-associated protein Tau, are a hallmark of Alzheimer disease. Lead is a potent neurotoxin for human being especially for the developing children, and Pb(2+) at high concentrations is found in the b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180286/ https://www.ncbi.nlm.nih.gov/pubmed/21966400 http://dx.doi.org/10.1371/journal.pone.0025020 |