Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin

PURPOSE: Luteinizing hormone receptor (LHR) is found in abundance on human ovarian, breast, endometrial and prostate carcinomas but at only low levels on non-gonadal tissues. To selectively kill LHR-expressing tumors, granzyme B (GrB) was linked to a protein in which both chains of human chorionic g...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanatani, Isao, Lin, Xinjian, Yuan, Xiaoqin, Manorek, Gerald, Shang, Xiying, Cheung, Lawrence H., Rosenblum, Michael G., Howell, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180622/
https://www.ncbi.nlm.nih.gov/pubmed/21327682
http://dx.doi.org/10.1007/s00280-011-1573-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180622/
https://www.ncbi.nlm.nih.gov/pubmed/21327682
http://dx.doi.org/10.1007/s00280-011-1573-4

Ejemplares similares