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Identification, localization, and relative quantitation of pseudouridine in RNA by tandem mass spectrometry of hydrolysis products
The constitutional isomers uridine (U) and pseudouridine (Ψ) cannot be distinguished from each other by simple mass measurements of RNA or its fragments because the conversion of U into Ψ is a “mass-silent” post-transcriptional modification. Here we propose a new mass spectrometry based method for i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180913/ https://www.ncbi.nlm.nih.gov/pubmed/21960742 http://dx.doi.org/10.1016/j.ijms.2010.05.024 |