Immortalization of MEF is characterized by the deregulation of specific miRNAs with potential tumor suppressor activity

The life span (Hayflick limit) of primary mouse embryo fibroblasts (MEF) in culture is variable but it is still unclear if the escape of the Hayflick limit is also variable. To address this point MEF were expanded every fifteen days (6T15) instead of every three days (6T3) until they became immortal...

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Detalles Bibliográficos
Autores principales: Rizzo, Milena, Evangelista, Monica, Simili, Marcella, Mariani, Laura, Pitto, Letizia, Rainaldi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181166/
https://www.ncbi.nlm.nih.gov/pubmed/21765199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181166/
https://www.ncbi.nlm.nih.gov/pubmed/21765199

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