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Individual Actin Filaments in a Microfluidic Flow Reveal the Mechanism of ATP Hydrolysis and Give Insight Into the Properties of Profilin

The hydrolysis of ATP associated with actin and profilin-actin polymerization is pivotal in cell motility. It is at the origin of treadmilling of actin filaments and controls their dynamics and mechanical properties, as well as their interactions with regulatory proteins. The slow release of inorgan...

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Detalles Bibliográficos
Autores principales: Jégou, Antoine, Niedermayer, Thomas, Orbán, József, Didry, Dominique, Lipowsky, Reinhard, Carlier, Marie-France, Romet-Lemonne, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181223/
https://www.ncbi.nlm.nih.gov/pubmed/21980262
http://dx.doi.org/10.1371/journal.pbio.1001161