Loss of p53 Ser18 and Atm Results in Embryonic Lethality without Cooperation in Tumorigenesis

Phosphorylation at murine Serine 18 (human Serine 15) is a critical regulatory process for the tumor suppressor function of p53. p53Ser18 residue is a substrate for ataxia-telangiectasia mutated (ATM) and ATM-related (ATR) protein kinases. Studies of mice with a germ-line mutation that replaces Ser1...

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Detalles Bibliográficos
Autores principales: Armata, Heather L., Shroff, Punita, Garlick, David E., Penta, Krista, Tapper, Andrew R., Sluss, Hayla K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181255/
https://www.ncbi.nlm.nih.gov/pubmed/21980358
http://dx.doi.org/10.1371/journal.pone.0024813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181255/
https://www.ncbi.nlm.nih.gov/pubmed/21980358
http://dx.doi.org/10.1371/journal.pone.0024813

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