PI3K and ERK-Induced Rac1 Activation Mediates Hypoxia-Induced HIF-1α Expression in MCF-7 Breast Cancer Cells

BACKGROUND: Hypoxia-inducible factor 1 (HIF-1α) expression induced by hypoxia plays a critical role in promoting tumor angiogenesis and metastasis. However, the molecular mechanisms underlying the induction of HIF-1α in tumor cells remain unknown. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we re...

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Detalles Bibliográficos
Autores principales: Du, Jun, Xu, Rui, Hu, Zhenzhen, Tian, Yinhui, Zhu, Yichao, Gu, Luo, Zhou, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181265/
https://www.ncbi.nlm.nih.gov/pubmed/21980400
http://dx.doi.org/10.1371/journal.pone.0025213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181265/
https://www.ncbi.nlm.nih.gov/pubmed/21980400
http://dx.doi.org/10.1371/journal.pone.0025213

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