Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lo...

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Detalles Bibliográficos
Autores principales: Huelsenbeck, J, Henninger, C, Schad, A, Lackner, K J, Kaina, B, Fritz, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181415/
https://www.ncbi.nlm.nih.gov/pubmed/21833028
http://dx.doi.org/10.1038/cddis.2011.65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181415/
https://www.ncbi.nlm.nih.gov/pubmed/21833028
http://dx.doi.org/10.1038/cddis.2011.65

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