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Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181415/ https://www.ncbi.nlm.nih.gov/pubmed/21833028 http://dx.doi.org/10.1038/cddis.2011.65 |