Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells

DNA interstrand cross-links (ICLs) are critical cytotoxic lesions produced by cancer chemotherapeutic agents such as the nitrogen mustards and platinum drugs; however, the exact mechanism of ICL-induced cell death is unclear. Here, we show a novel mechanism of p53-independent apoptotic cell death in...

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Detalles Bibliográficos
Autores principales: Osawa, T, Davies, D, Hartley, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181417/
https://www.ncbi.nlm.nih.gov/pubmed/21814285
http://dx.doi.org/10.1038/cddis.2011.70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181417/
https://www.ncbi.nlm.nih.gov/pubmed/21814285
http://dx.doi.org/10.1038/cddis.2011.70

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