The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson's disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests that LR...

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Detalles Bibliográficos
Autores principales: Lichtenberg, M, Mansilla, A, Zecchini, V R, Fleming, A, Rubinsztein, D C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181424/
https://www.ncbi.nlm.nih.gov/pubmed/21866175
http://dx.doi.org/10.1038/cddis.2011.81

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181424/
https://www.ncbi.nlm.nih.gov/pubmed/21866175
http://dx.doi.org/10.1038/cddis.2011.81

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