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The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson's disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests that LR...

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Detalles Bibliográficos
Autores principales:	Lichtenberg, M, Mansilla, A, Zecchini, V R, Fleming, A, Rubinsztein, D C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181424/ https://www.ncbi.nlm.nih.gov/pubmed/21866175 http://dx.doi.org/10.1038/cddis.2011.81

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