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Unique molecular signatures of disease brain endothelia provide a novel site for CNS-directed enzyme therapy
The brain vasculature forms an immense network such that most neural cells are in contact with a microvessel. Here we tested the hypothesis that endothelia lining these vessels can be harnessed to create a cellular reservoir of enzyme replacement therapy to diseased brain. As a model system, we used...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181494/ https://www.ncbi.nlm.nih.gov/pubmed/19749771 http://dx.doi.org/10.1038/nm.2025 |