E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

The carboxyl terminus of constitutive heat shock cognate 70 (HSC70)–interacting protein (CHIP, also known as Stub1) is a U box–containing E3 ubiquitin ligase that is important for protein quality control. The role of CHIP in innate immunity is not known. Here, we report that CHIP knockdown inhibits...

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Detalles Bibliográficos
Autores principales: Yang, Mingjin, Wang, Chen, Zhu, Xuhui, Tang, Songqing, Shi, Liyun, Cao, Xuetao, Chen, Taoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182058/
https://www.ncbi.nlm.nih.gov/pubmed/21911421
http://dx.doi.org/10.1084/jem.20102667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182058/
https://www.ncbi.nlm.nih.gov/pubmed/21911421
http://dx.doi.org/10.1084/jem.20102667

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