Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

Activating mutations in protein tyrosine phosphatase 11 (Ptpn11) have been identified in childhood acute leukemias, in addition to juvenile myelomonocytic leukemia (JMML), which is a myeloproliferative disorder (MPD). It is not clear whether activating mutations of this phosphatase play a causal rol...

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Detalles Bibliográficos
Autores principales: Xu, Dan, Liu, Xia, Yu, Wen-Mei, Meyerson, Howard J., Guo, Caiying, Gerson, Stanton L., Qu, Cheng-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182060/
https://www.ncbi.nlm.nih.gov/pubmed/21930766
http://dx.doi.org/10.1084/jem.20110450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182060/
https://www.ncbi.nlm.nih.gov/pubmed/21930766
http://dx.doi.org/10.1084/jem.20110450

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