Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

Previous studies have shown that inducing autophagy ameliorates early cognitive deficits associated with the build-up of soluble amyloid-β (Aβ). However, the effects of inducing autophagy on plaques and tangles are yet to be determined. While soluble Aβ and tau represent toxic species in Alzheimer&#...

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Detalles Bibliográficos
Autores principales: Majumder, Smita, Richardson, Arlan, Strong, Randy, Oddo, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182203/
https://www.ncbi.nlm.nih.gov/pubmed/21980451
http://dx.doi.org/10.1371/journal.pone.0025416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182203/
https://www.ncbi.nlm.nih.gov/pubmed/21980451
http://dx.doi.org/10.1371/journal.pone.0025416

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