A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy

The role of estrogens in Alzheimer's disease (AD) involving β-amyloid (Aβ) generation and plaque formation was mostly tested in ovariectomized mice with or without APP mutations. The aim of the present study was to explore the abnormalities of neural cells in a novel mouse model of AD with chro...

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Detalles Bibliográficos
Autores principales: Prat, Annik, Behrendt, Maik, Marcinkiewicz, Edwige, Boridy, Sebastien, Sairam, Ram M., Seidah, Nabil G., Maysinger, Dusica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182380/
https://www.ncbi.nlm.nih.gov/pubmed/21969914
http://dx.doi.org/10.4061/2011/251517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182380/
https://www.ncbi.nlm.nih.gov/pubmed/21969914
http://dx.doi.org/10.4061/2011/251517

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