Cargando…

A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy

The role of estrogens in Alzheimer's disease (AD) involving β-amyloid (Aβ) generation and plaque formation was mostly tested in ovariectomized mice with or without APP mutations. The aim of the present study was to explore the abnormalities of neural cells in a novel mouse model of AD with chro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prat, Annik, Behrendt, Maik, Marcinkiewicz, Edwige, Boridy, Sebastien, Sairam, Ram M., Seidah, Nabil G., Maysinger, Dusica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182380/ https://www.ncbi.nlm.nih.gov/pubmed/21969914 http://dx.doi.org/10.4061/2011/251517

Ejemplares similares

The Multifaceted Biology of PCSK9
por: Seidah, Nabil G, et al.
Publicado: (2021)

Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
por: Boridy, S, et al.
Publicado: (2014)

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model
por: Sun, Xiaowei, et al.
Publicado: (2009)

Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid
por: Chang, P. K.-Y., et al.
Publicado: (2013)

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development
por: Szumska, Dorota, et al.
Publicado: (2017)

PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis
por: Pelletier, R.-Marc, et al.
Publicado: (2022)

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)
por: Canuel, Maryssa, et al.
Publicado: (2013)

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth
por: Declercq, Jeroen, et al.
Publicado: (2015)

Nutritional and Nanotechnological Modulators of Microglia
por: Maysinger, Dusica, et al.
Publicado: (2016)

Three-dimensional reconstruction of cell nuclei, internalized quantum dots and sites of lipid peroxidation
por: Funnell, W Robert J, et al.
Publicado: (2006)

Dendrimers as Modulators of Brain Cells
por: Maysinger, Dusica, et al.
Publicado: (2020)

Insights into the role of estrogens and androgens in glial tumorigenesis
por: Daswani, Bhavna, et al.
Publicado: (2021)

Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology
por: Avti, Pramod K., et al.
Publicado: (2013)

Nanoparticle-Based and Bioengineered Probes and Sensors to Detect Physiological and Pathological Biomarkers in Neural Cells
por: Maysinger, Dusica, et al.
Publicado: (2015)

Gold Nanoparticles Impinge on Nucleoli and the Stress Response in MCF7 Breast Cancer Cells
por: Kodiha, Mohamed, et al.
Publicado: (2016)

Insights into Interactions between Interleukin-6 and Dendritic Polyglycerols
por: Sanader Maršić, Željka, et al.
Publicado: (2021)

Renal Hypertrophy in Mice Receiving Estrogens and Androgens
por: Pfeiffer, Carroll A., et al.
Publicado: (1940)

Open questions on proteins interacting with nanoclusters
por: Antoine, Rodolphe, et al.
Publicado: (2022)

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation
por: Seidah, Nabil G., et al.
Publicado: (2012)

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor
por: Grin, Peter M., et al.
Publicado: (2018)

Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a)
por: Clark, Justin R., et al.
Publicado: (2022)

Estrogen regulates histone deacetylases to prevent cardiac hypertrophy
por: Pedram, Ali, et al.
Publicado: (2013)

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
por: Yazdani, Hossein, et al.
Publicado: (2020)

Glial influence on the Blood Brain Barrier
por: Alvarez, Jorge Ivan, et al.
Publicado: (2013)

Off to the Organelles - Killing Cancer Cells with Targeted Gold Nanoparticles
por: Kodiha, Mohamed, et al.
Publicado: (2015)

Encapsulation and Delivery of Neutrophic Proteins and Hydrophobic Agents Using PMOXA–PDMS–PMOXA Triblock Polymersomes
por: Moquin, Alexandre, et al.
Publicado: (2018)

MeCP2 Deficiency Leads to Loss of Glial Kir4.1
por: Kahanovitch, Uri, et al.
Publicado: (2018)

In vivo Imaging of Glial Activation in Alzheimer's Disease
por: Edison, Paul, et al.
Publicado: (2018)

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease
por: Al-Ghraiybah, Nour F., et al.
Publicado: (2022)

The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol
por: Seidah, Nabil G.
Publicado: (2017)

The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer
por: Seidah, Nabil G.
Publicado: (2021)

Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells
por: Choi, Angela O, et al.
Publicado: (2007)

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
por: Chang, Philip K-Y, et al.
Publicado: (2015)

Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model
por: Aerts, Laetitia, et al.
Publicado: (2013)

JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer’s disease model
por: Jeong, Jihoon, et al.
Publicado: (2020)

Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter
por: Traboulsi, Hussein, et al.
Publicado: (2017)

Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice
por: Sun, Junming, et al.
Publicado: (2021)

Glial activation and inflammation along the Alzheimer’s disease continuum
por: Nordengen, Kaja, et al.
Publicado: (2019)

Retinal glial changes in Alzheimer's disease – A review
por: Fernández-Albarral, José A., et al.
Publicado: (2019)

The Implication of Glial Metabotropic Glutamate Receptors in Alzheimer’s Disease
por: de Lima, Izabella B.Q., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dh8tad26jnrrt2ldfq6amg5m6s