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Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
Regioselective bromine–lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the bi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182437/ https://www.ncbi.nlm.nih.gov/pubmed/21977212 http://dx.doi.org/10.3762/bjoc.7.148 |
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author | Bonnafoux, Laurence Leroux, Frédéric R Colobert, Françoise |
author_facet | Bonnafoux, Laurence Leroux, Frédéric R Colobert, Françoise |
author_sort | Bonnafoux, Laurence |
collection | PubMed |
description | Regioselective bromine–lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically. |
format | Online Article Text |
id | pubmed-3182437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-31824372011-10-05 Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands Bonnafoux, Laurence Leroux, Frédéric R Colobert, Françoise Beilstein J Org Chem Full Research Paper Regioselective bromine–lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically. Beilstein-Institut 2011-09-14 /pmc/articles/PMC3182437/ /pubmed/21977212 http://dx.doi.org/10.3762/bjoc.7.148 Text en Copyright © 2011, Bonnafoux et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Bonnafoux, Laurence Leroux, Frédéric R Colobert, Françoise Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands |
title | Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands |
title_full | Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands |
title_fullStr | Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands |
title_full_unstemmed | Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands |
title_short | Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands |
title_sort | bromine–lithium exchange: an efficient tool in the modular construction of biaryl ligands |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182437/ https://www.ncbi.nlm.nih.gov/pubmed/21977212 http://dx.doi.org/10.3762/bjoc.7.148 |
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