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Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands

Regioselective bromine–lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the bi...

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Autores principales: Bonnafoux, Laurence, Leroux, Frédéric R, Colobert, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182437/
https://www.ncbi.nlm.nih.gov/pubmed/21977212
http://dx.doi.org/10.3762/bjoc.7.148
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author Bonnafoux, Laurence
Leroux, Frédéric R
Colobert, Françoise
author_facet Bonnafoux, Laurence
Leroux, Frédéric R
Colobert, Françoise
author_sort Bonnafoux, Laurence
collection PubMed
description Regioselective bromine–lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically.
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spelling pubmed-31824372011-10-05 Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands Bonnafoux, Laurence Leroux, Frédéric R Colobert, Françoise Beilstein J Org Chem Full Research Paper Regioselective bromine–lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically. Beilstein-Institut 2011-09-14 /pmc/articles/PMC3182437/ /pubmed/21977212 http://dx.doi.org/10.3762/bjoc.7.148 Text en Copyright © 2011, Bonnafoux et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Bonnafoux, Laurence
Leroux, Frédéric R
Colobert, Françoise
Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
title Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
title_full Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
title_fullStr Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
title_full_unstemmed Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
title_short Bromine–lithium exchange: An efficient tool in the modular construction of biaryl ligands
title_sort bromine–lithium exchange: an efficient tool in the modular construction of biaryl ligands
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182437/
https://www.ncbi.nlm.nih.gov/pubmed/21977212
http://dx.doi.org/10.3762/bjoc.7.148
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