5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals

5-HT3A receptors select among permeant ions based on size and charge. The membrane-associated (MA) helix lines the portals into the channel’s cytoplasmic vestibule in the 4-Å resolution structure of the homologous acetylcholine receptor. 5-HT3A MA helix residues are important determinants of single-...

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Detalles Bibliográficos
Autores principales: McKinnon, Nicole K., Reeves, David C., Akabas, Myles H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182448/
https://www.ncbi.nlm.nih.gov/pubmed/21948949
http://dx.doi.org/10.1085/jgp.201110686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182448/
https://www.ncbi.nlm.nih.gov/pubmed/21948949
http://dx.doi.org/10.1085/jgp.201110686

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