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Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer
Anomalous self-assembly of the Aβ peptide into fibrillar amyloid deposits is strongly correlated with the development of Alzheimer's disease. Aβ fibril extension follows a template guided “dock and lock” mechanism where polymerisation is catalysed by the fibrillar ends. Using surface plasmon re...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182996/ https://www.ncbi.nlm.nih.gov/pubmed/21980388 http://dx.doi.org/10.1371/journal.pone.0025157 |