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Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer

Anomalous self-assembly of the Aβ peptide into fibrillar amyloid deposits is strongly correlated with the development of Alzheimer's disease. Aβ fibril extension follows a template guided “dock and lock” mechanism where polymerisation is catalysed by the fibrillar ends. Using surface plasmon re...

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Detalles Bibliográficos
Autores principales:	Brännström, Kristoffer, Öhman, Anders, Olofsson, Anders
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182996/ https://www.ncbi.nlm.nih.gov/pubmed/21980388 http://dx.doi.org/10.1371/journal.pone.0025157

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