Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

LATS2 kinase functions as part of the Hippo pathway to promote contact inhibition of growth and tumor suppression by phosphorylating and inhibiting the transcriptional coactivator YAP. LATS2 is activated by the MST2 kinase. How LATS2 is activated by MST2 in response to changes in cell density is unk...

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Detalles Bibliográficos
Autores principales: Paramasivam, Murugan, Sarkeshik, Ali, Yates, John R., Fernandes, Maria J. G., McCollum, Dannel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183025/
https://www.ncbi.nlm.nih.gov/pubmed/21832154
http://dx.doi.org/10.1091/mbc.E11-04-0300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183025/
https://www.ncbi.nlm.nih.gov/pubmed/21832154
http://dx.doi.org/10.1091/mbc.E11-04-0300

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