Inhibition of Glycogen Synthase Kinase-3β Counteracts Ligand-Independent Activity of the Androgen Receptor in Castration Resistant Prostate Cancer

In order to generate genomic signals, the androgen receptor (AR) has to be transported into the nucleus upon androgenic stimuli. However, there is evidence from in vitro experiments that in castration-resistant prostate cancer (CRPC) cells the AR is able to translocate into the nucleus in a ligand-i...

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Detalles Bibliográficos
Autores principales: Schütz, Stefanie V., Schrader, Andres J., Zengerling, Friedemann, Genze, Felicitas, Cronauer, Marcus V., Schrader, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183056/
https://www.ncbi.nlm.nih.gov/pubmed/21980429
http://dx.doi.org/10.1371/journal.pone.0025341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183056/
https://www.ncbi.nlm.nih.gov/pubmed/21980429
http://dx.doi.org/10.1371/journal.pone.0025341

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